Welcome To Venocin

What is Venocin

Venocin is a standardized extract obtained from the seeds of the Horse Chestnut (Aesculus hippocastanum L.) tree. The extract is standardized to contain a minimum of 20% escin (for oral administration) or 90% escin (for topical applications). Escin is a mixture of saponins that is known to help maintain healthy blood circulation and strengthen the capillaries and veins. Horse chestnut extract is clinically proven to be beneficial to people suffering from varicose veins, spider veins, hemorrhoids and related circulatory problems or "chronic venous insufficiency" (CVI) ...


Topical Applications of Venocin

Proprietary preparations containing escin have been marketed for several years in Europe as a topical therapeutic measure in the management of CVI, peripherial vascular disease and in dental practice.

Evidence for the efficacy and safety of various topical formulations of escin has been obtained in preclinical and clinical studies. Over thirteen clinical studies were performed in Europe. A 2% escin preparation was found to penetrate the subcutis and the underlying muscle. In animal model studies based on the croton oil dermatitis model, the complex of escin with Β-sitosterol and phosphatidylcholine was found to be more effective than free escin ...


Clinical Studies

European researchers have conducted a number of clinical studies over the past few decades. Pittler and Ernst17,18 summarized these studies in a literature review to evaluate the evidence for or against the use of HCSE and isolated escin in the management of venous insufficiency (summarized in Appendix 1).

Their review describes the protocols and findings of 13 randomized controlled trials of horse-chestnut seed extract. Eight of the studies were placebo-controlled trials and five were comparative evaluations against reference medications. 20 to 226 subjects participated in each of these placebo-controlled trials, for periods ranging from 20 days to eight weeks ...


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