Venocin® is a standardized extract prepared from the seeds of the Horse Chestnut (Aesculus hippocastanum L.) tree. The extract is standardized to contain a minimum of 20% escin (intended for dietary ingredient) and 90% escin (used cosmetic ingredient). Escin is a mixture of saponins that are known to help maintain healthy circulatory system by strengthening the capillaries and veins. INCI: Aesculus Hippocastanum (Horse Chestnut) Seed Extract
The horse chestnut seeds are rich in saponins (3–5%) out of which thirty molecules are isolated and characterized. The principal biologically active component of horse chestnut seed extract is escin.
The authors concluded that topical application of the escin complex improves skin and adipose tissue microcirculation, increases blood flow at the capillary level and decreases edema and stasis.
The supplementation of the horse chestnut extract improved the condition and the effect was comparable to standard compression therapy with better compliance.