The supplementation of the horse chestnut extract improved the condition and the effect was comparable to standard compression therapy with better compliance.
The horse chestnut seeds are rich in saponins (3–5%) out of which thirty molecules are isolated and characterized. The principal biologically active component of horse chestnut seed extract is escin.
The authors concluded that topical application of the escin complex improves skin and adipose tissue microcirculation, increases blood flow at the capillary level and decreases edema and stasis.
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