The principal biologically active component of horse chestnut seed extract is escin, a triterpenic saponin mixture. Other compounds such as proanthocyanidin A2 and esculin are also reported to be beneficial in the management of CVI.4 Recent structural evidence reveals that the two major glycosides in the escin mixture contain the aglycone protoescigenin, glucuronic acid and two glucose molecules. The two aglycones differ only at the C-21 position which is acylated by either angelic acid or tigilic acid5.

Escin Chart


Other biologically active components in HCSE include the bioflavonoid Proanthocyanidin A2 and the coumarin, esculin.

Proanthocyanidin Chart

Proanthocyanidin A2

Esculin Chart


The anti-edema, anti-exudative and vasoprotective actions are reported to be mainly due to escin6. Orally and topically administered proanthocyanidin A2 is reported to have wound healing actions4. Esculin is reported to be useful in improving microcirculation4.


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.