Recommended Dosage

The oral LD50 of horse chestnut seed extract is 990 mg/kg body weight in the mouse, 2150 mg/kg body weight in the rat, 1530 mg/kg body weight in the rabbit and 1120 mg/kg body weight in the guinea pig40. Doses between 9 and 30 mg/kg body weight intravenously administered to the rat for 8 weeks had no adverse effects. Chronic administration of above 80 mg/kg body weight in dogs over a period of 34 weeks produced gastric irritation while in rats, no toxic effects were observed over the same period up to an oral dose of 400 mg/kg body weight1,40.

As reported in literature sources, HCSE are relatively safe; they have low acute and chronic toxicity, and a high therapeutic index23.

Data from the reported studies showed that therapeutic benefit was derived from oral doses of horse-chestnut seed extract equivalent to 100 to 150 mg of escin daily. In two of the placebo-controlled studies, daily doses of 100 mg of escin resulted in a significant reduction in the mean leg volume after two weeks of therapy16. In one study, two capsules per day , each containing 300 mg of HCSE, standardized to contain 50 mg escin, taken for 12 weeks, were effective in patients suffering from CVI18. For topical use, gel formulations containing 2% escin and emulsions containing 3% esculin are proven to be beneficial in cases of venous insufficiency.4

In animal studies and in clinical trials, horse chestnut and its principal ingredient escin have been found to be safe. Individuals with severe kidney problems should avoid horse chestnut.24,25 In view of its pharmacological effects, horse chestnut extract should not be combined with anticoagulant or "blood-thinning" therapies, as it may potentiate their effects.26,27 The safety of horse chestnut in young children and pregnant or nursing women has not yet been established.

Thus in combination with adequate physical measures and dietary supplementation, Venocin is beneficial in cases of CVI. Physical measures include adequate exercise, avoiding long hours of standing, and using compression stockings and dietary supplementation include a high-fiber diet supplied by fruits, vegetables and natural fiber2.