Venocin™ is a standardized extract obtained from the seeds of the Horse Chestnut (Aesculus hippocastanum L.) tree. The extract is standardized to contain a minimum of 20% escin (for oral administration) or 90% escin (for topical applications). Escin is a mixture of saponins that is known to help maintain healthy blood circulation and strengthen the capillaries and veins. Horse chestnut extract is clinically proven to be beneficial to people suffering from varicose veins, spider veins, hemorrhoids and related circulatory problems or "chronic venous insufficiency" (CVI). Chronic venous insufficiency is described as an advanced stage of venous disease caused either by superficial (severe varicose veins) or deep venous abnormalities that could lead to venous thrombosis. A characteristic effect of this condition is increased venous pressure during walking, that induces symptoms such as leg swelling, leg pain, and muscle cramps.
The horse chestnut tree, indigenous to Asia and northern Greece is now cultivated in many areas of Europe and North America. The fruit is made up of a spiny capsule containing one to three large seeds. Traditionally, the seeds, leaves, and bark, were used in medicinal preparations. More recently, horse chestnut extract is valued as a nutritional supplement beneficial to circulatory system. Horse chestnut seed extract is the traditional remedy for CVI, varicose veins, hemorrhoids, and phlebitis (inflammation of the veins) in Europe, where the extract has been subjected to a number of clinical trials1.